Realizing Elementary Discrete Repertoire Clonal Selection Algorithms
نویسنده
چکیده
The natural progression from a clonal selection algorithm, is to employ that algorithm in a loose architectural model of the acquired immune system. A series of multiple discrete repertoire models were previously proposed to do just that. These models are briefly reviewed in this work, and elaborated to a multiple repertoire system. This system is defined in the context of a series of principle effects, design principles and behavioural expectations. It is demonstrated that the path to realizing this broader system is to employ a bottom-up approach using a number of low-level algorithms. This work completes with a summary of a number of experimental investigations and studies that provide a framework for further extensions of this
منابع مشابه
Realizing Elementary Clonal Selection Algorithms
A series of acquired immunity inspired clonal selection models have previously been proposed that includes principle model components and base (single repertoire) models. Also previously proposed is a contrived problem domain called ‘colour space’ and a number of scenarios intended for the investigation of adaptive models. This work units these two (until now) isolated streams of work by realiz...
متن کاملReconstructing and mining the B cell repertoire with ImmunediveRsity
The B cell antigen receptor repertoire is highly diverse and constantly modified by clonal selection. High-throughput DNA sequencing (HTS) of the lymphocyte repertoire (Rep-Seq) represents a promising technology to explore such diversity ex-vivo and assist in the identification of antigen-specific antibodies based on molecular signatures of clonal selection. Therefore, integrative tools for rep...
متن کاملAn Intra-Repertoire Recognition Algorithm
The network theory of immunology proposes that antigen receptors themselves provide units for selection by antireceptor receptors. This work discusses the implication of receptor-receptor recognition in the context of a previously developed elaborated clonal selection algorithm (ECSA). The result is a pattern recognition-based system capable of cognitive tasks that surpass the simple ECSA, and ...
متن کاملNarrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response
T cell immunity relies on the generation and maintenance of a diverse repertoire of T cell antigen receptors (TCRs). The strength of signaling emanating from the TCR dictates the fate of T cells during development, as well as during the immune response. Whereas development of new T cells in the thymus increases the available TCR repertoire, clonal selection during the immune response narrows TC...
متن کاملA hybrid CS-SA intelligent approach to solve uncertain dynamic facility layout problems considering dependency of demands
This paper aims at proposing a quadratic assignment-based mathematical model to deal with the stochastic dynamic facility layout problem. In this problem, product demands are assumed to be dependent normally distributed random variables with known probability density function and covariance that change from period to period at random. To solve the proposed model, a novel hybrid intelligent algo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007